Protein structures

NMR protein structures co-authored by P. Güntert.

	Ghosh, D., Torres, F., Schneider, M. M., Ashkinadze, D., Kadavath, H., Fleischmann, Y., Mergenthal, S., Güntert, P. , Krainer, G., Andrzejewska, E. A., Lin, L., Wei, J., Klotzsch, E., Knowles, T. & Riek, R. The inhibitory action of the chaperone BRICHOS against α-Synuclein secondary nucleation pathway at near-atomic resolution. Nat. Commun. 15, 10038 (2024) PDB 8OVI NMR data BMRB 34811 (monomer) PDB 8OX2 NMR data BMRB 34813 (trimer)
	Kuwasako, K., Dang, W., Fahu, H., Takahashi, M., Tsuda, K., Nagata, T., Tanaka, A., Kobayashi, N., Kigawa, T., Güntert, P., Shirouzu, M., Yokoyama, S. & Muto, Y. 1H, 13C and 15N resonance assignments and solution structure of the N-terminal divergent caplonin homology (NN-CH) domain of human intraflagellar transport protein 54. Biomol. NMR Assignments 18, 71–78 (2024) PDB 8KCQ NMR data BMRB 36589
	Rüdisser, S. H., Matabaro, E., Sonderegger, L., Güntert, P., Künzler, M., Gossert, A. D. Conformations of macrocyclic peptides sampled by exact NOEs: Models for cell-permeability. J. Am. Chem. Soc. 145, 27601–27615 (2023) PDB 8QBP NMR data BMRB 34850 (OmphA “indole-In) PDB 8Q7J NMR data BMRB 34846 (CsA) PDB 8QAQ NMR data BMRB 34848 (OmphA conformation 1) PDB 8QAS NMR data BMRB 34849 (OmphA “indole-Out”)
	Rout, S. K., Cadalbert, R., Schröder, N., Wang, J., Zehnder, J., Gampp, O., Wiegand, T., Güntert, P. , Klingler, D., Kreutz, C., Knörlein, A., Hall, J., Greenwald, J. & Riek, R. An analysis of nucleotide-amyloid interactions reveals selective binding to codon-sized RNA. J. Am. Chem. Soc. 145, 21915−21924 (2023) PDB 8PXS NMR data BMRB 34838
	Kuwasako, K., Suzuki, S., Nameki, N., Takizawa, M., Takahashi, M., Tsuda, K., Nagata, T., Watanabe, S., Tanaka, A., Kobayashi, N., Kigawa, T., Güntert, P., Shirouzu, M., Yokoyama, S. & Muto, Y. 1H, 13C and 15N resonance assignments and solution structures of the KH domain of ribosome binding factor A, mtRbfA, from humans, that is involved in mitochondrial ribosome biogenesis. Biomol. NMR Assignments 16, 297–303 (2022) PDB 7X9U NMR data BMRB 36478
	Gerez, J. A., Prymaczok, N. C., Kadavath, H., Ghosh, D., Bütikofer, M., Güntert, P. & Riek, R. Protein structure determination in human cells by in-cell NMR and a reporter system to optimize protein delivery or transexpression. Comm. Biol. 5, 1322 (2022) PDB 7QTR NMR data BMRB 34700 (GB1 in cells at a protein concentration of 50 μM) PDB 7QTS NMR data BMRB 34701 (GB1 in cells at a protein concentration of 10 μM)
	Ashkinadze, D., Kadavath, H., Chi, C., Friedmann, M., Strotz, D., Kumari, P., Minges, M., Cadalbert, C., Königl, S., Güntert, P., Vögeli, B. & Riek, R. Atomic resolution protein allostery from the multi-state structure of a PDZ Domain. Nat. Commun. 13, 6232 (2022) PDB 7QCX NMR data BMRB 34688 (two-state structure of apo PDZ2) PDB 7QCY NMR data BMRB 34689 (two-state structure of PDZ2 complexed with RA-GEF2 peptide)
	He., F., Kuwasako, K., Takizawa, M., Takahashi, M., Tsuda, K., Nagata, T., Watanabe, S., Tanaka, A., Kobayashi, N., Kigawa, T., Güntert, P., Shirouzu, M., Yokoyama, S. & Muto, Y. 1H, 13C and 15N resonance assignments and solution structures of the two RRM domains of Matrin-3. Biomol. NMR Assignments 16, 41–49 (2022) PDB 7FBR NMR data BMRB 36430 (first RRM domain of Matrin-3) PDB 7FBV NMR data BMRB 36431 (second RRM domain of Matrin-3)
	Seuring, C., Verasdonck, J., Gath, J., Ghosh, D., Nespovitaya, N., Wälti, M. A., Maji, S., Cadalbert, R., Güntert, P., Meier, B. H. & Riek, R. The three-dimensional structure of human β-endorphin amyloid fibrils. Nat. Struct. Mol. Biol. 27, 1178–1184 (2020) PDB 6TUB NMR data BMRB 26715
	Strotz, D., Orts, J., Kadavath, H., Friedmann, M., Ghosh, D., Olsson, S., Chi, C. N., Pokharna, A., Güntert, P., Vögeli, B. & Riek, R. Protein allostery at atomic resolution. Angew. Chem. Int. Ed. 59, 22132-22139 (2020) PDB 6SVC NMR data BMRB 34432 (WW domain apo structure) PDB 6SVE NMR data BMRB 34433 (WW domain with pCdc25C bound) PDB 6SVH NMR data BMRB 34434 (WW domain with FFpSPR bound)
	Beil, A., Jurt, S., Walser, R., Schäfer, T., Güntert, P., Capdeville, M., Atrian, S., Dallinger, R. & Zerbe, O. The solution structure and dynamics of Cd-metallothionein from Helix pomatia reveal optimization for binding Cd over Zn. Biochemistry. Biochemistry 58, 4570-4581 (2019) PDB 6QK5 NMR data BMRB 34355 (Zn-loaded form) PDB 6QK6 NMR data BMRB 34356 (Cd-loaded form)
	Tanaka, T., Ikeya, T., Kamoshida, H., Suemoto, Y., Mishima, M., Shirakawa, M., Güntert, P., Ito, Y. High resolution protein 3D structure determination in living eukaryotic cells. Angew. Chem. Int. Ed. 58, 7284–7288 (2019) PDB 5ZCZ NMR data BMRB 27354 (T. thermophilus HB8 TTHA1718 protein in living eukaryotic cells) PDB 5ZD0 NMR data BMRB 27356 (ubiquitin with three alanine mutations in living eukaryotic cells) PDB 5Z4B NMR data BMRB 36153 (GB1 in living eukaryotic cells)
	Huber, J., Obata, M., Gruber, J., Akutsu, M., Löhr, F., Rogova, N., Güntert, P., Dikic, I., Krikin, V., Komatsu, M., Dötsch, V. & Rogov, V. V. An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5. Autophagy 16, 256-270 (2020) PDB 6H8C NMR data BMRB 34307 (GABARAPL2 in complex with UBA5 LIR motif) PDB 6HB9 NMR data (crystal structure of GABARAP in complex with UBA5 LIR motif)
	Kniss, A., Kazemi, S., Löhr, F., Berger, M., Rogov, V. V., Güntert, P., Sommer, T., Jarosch, E. & Dötsch, V. Structural investigation of glycan recognition by the ERAD quality control lectin Yos9. J. Biomol. NMR 72, 1-10 (2018) PDB 6F98 NMR data BMRB 34217 (RING domain of E3 ubiquitin ligase HRD1) PDB 6F99 NMR data BMRB 34218 (MRH domain of Yos9) PDB 6F9A NMR data BMRB 34219 (MRH domain of Yos9 complexed with alpha3,alpha6-Man5)
	Jemth, P., Andersson, E., Vögeli, B., Hultqvist, G., Dogan, J., Güntert, P. & Riek, R. & Chi, C. N., Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins. Science Adv. 4, eaau4130 (2018) PDB 6ES5 NMR data BMRB 34187 PDB 6ES6 NMR data BMRB 34188 PDB 6ES7 NMR data BMRB 34189
	Sundell, G. N., Arnold, R., Ali, M., Naksukpaiboon, P., Orts, J., Güntert, P., Chi, C. N., Ivarsson, Y. Proteome-wide analysis of phospho-regulated PDZ domain interactions. Mol. Sys. Biol. 14, e8129 (2018) PDB 6ESP NMR data BMRB 34190
	Nichols, P.J., Henen, M.A., Born, A., Strotz, D., Guntert, P., Vogeli, B. High-resolution small RNA structures from exact nuclear Overhauser enhancement measurements without additional restraints. . [Commun Biol 2018] PDB 6BY4 NMR data BMRB 30386 PDB 6BY5 NMR data BMRB 30386
	Krauskopf, K., Gebel, J., Kazemi, S., Löhr, F., Tuppi, M., Löhr, F., Schäfer, B., Koch, J., Güntert, P., Dötsch, V. & Kehrloesser, S. Regulation of the activity in the p53 family depends on the organization of the transactivation domain. Structure 26, 1091–1100 (2018) PDB 6FGN NMR data BMRB 34231 PDB 6FGS NMR data BMRB 34233
	Gauto, D. F., Estrozi, L. F., Schwieters, C. D., Effantin, G., Macek, P., Sounier, R., Sivertsen, A. C., Schmidt, E., Kerfah, R., Mas, G., Colletier, J.-P., Güntert, P., Favier, A., Schoehn, G., Schanda, P. & Boisbouvier, J. Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. Nat. Commun. 10, 2697 (2019) PDB 6F3K NMR data BMRB 27211 (NMR + EM structure) PDB 6R8N NMR data BMRB 27211 (NMR + EM structure after Phenix refinement)
	Russo, C., Osterburg, C., Sirico, A., Antonini, D., Ambrosio, R., Würz, J. M., Rinnental J., Schäfer, B., Güntert, P., Sinha, S., Dötsch, V. & Missero, C. Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome. Proc. Natl. Acad. Sci. USA 115, E906-E915 (2018) PDB 5N2O NMR data BMRB 34095
	Reckel, S., Gehin, C., Tardivon, D., Harduin, D., Georgeon, S., Kükenshöner, T., Löhr, F., Koide, A., Buchner, L., Panjkovich, A., Reynaud, A., Pinho, S., Gerig, B., Svergun, D., Pojer, F., Güntert, P., Dötsch, V., Koide, S., Gavin, A.-C. & Hantschel, O. Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat. Commun. 8, 2101 (2017) PDB 5N6R NMR restraints BMRB 34101 (DH NMR structure) PDB 5N7E (DH/Mb(Bcr-DH_4)) PDB 5OC7 (PH/Mb(Bcr-PH_4))
	Bibow, S., Polyhach, Y., Eichmann, C., Chi, C. N., Kowal, J., Albiez, S., McLeod, R. A., Stahlberg, H., Jeschke, G., Güntert, P. & Riek, R. Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I. Nat. Struct. Mol. Biol. 24, 187-193 (2017) PDB 2N5E NMR restraints BMRB 25710
	Kuwasako, K., Nameki, N., Tsuda, K., Takahashi, M., Sato, A., Tochio, N., Inoue, M., Terada, T., Kigawa, T., Kobayashi, N., Shirouzu, M., Ito, T., Sakamoto, T., Wakamatsu, K., Güntert, P., Takahashi, S., Yokoyama, S. & Muto, Y. Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment. Protein Sci. 26, 280-291 (2017) PDB 5GVQ NMR restraints BMRB 36018
	Ikeya, T., Hanashima, T., Hosoya, S., Shimazaki, M., Ikeda, S., Mishima, M., Güntert, P. & Ito, Y. Improved in-cell structure determination of proteins at near-physiological concentration. Sci Rep. 6, 38312 (2016) PDB 2N9L NMR restraints BMRB 25910
	Gebel, J., Luh, L. M., Coutandin, D., Osterburg, C., Löhr, F., Schäfer, B., Frombach, A., Sumyk, M., Buchner, L., Krojer, T., Salah, E., Mathea, S., Güntert, P., Knapp, S. & Dötsch, V. Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization. Cell Death Diff. 23, 1930-1940 (2016) PDB 2NB1 NMR restraints BMRB 25958
	Wälti, M. A., Ravotti, F., Arai, H., Glabe, C., Wall, J., Böckmann, A., Güntert, P., Meier, B. H. & Riek, R. Atomic resolution structure of a disease-relevant Aβ(1–42) amyloid fibril. Proc. Natl. Acad. Sci. USA PDB 2NAO NMR restraints BMRB 26692
	von Delbrück, M., Kniss, A., Rogov, V. V., Pluska, L., Bagola, K., Löhr, F., Güntert, P., Sommer, T. & Dötsch, V. The CUE domain of Cue1 aligns growing ubiquitin chains with Ubc7 for rapid elongation. Mol. Cell 62, 918-928 (2016) PDB 2MYX NMR restraints BMRB 25461
	Huang, S. Y., Chang, C. F., Fan, P. J., Naik, M. T., Güntert, P., Shih, H. M. & Huang, T. H. The RING domain of human promyelocytic leukemia protein (PML). J. Biomol. NMR 61, 173-180 (2015) PDB 2MWX NMR restraints BMRB 25376
	Schütz, A. K., Vagt, T., Huber, M., Ovchinnikova, O. Y., Cadalbert, R., Wall, J., Güntert, P., Böckmann, A., Glockshuber, R., and Meier, B. H. Atomic-resolution three-dimensional structure of amyloid β fibrils bearing the Osaka mutation. Angew. Chem. Int. Ed. 54, 331–335 (2015) PDB 2MVX NMR restraints BMRB 25289
	Tsuda, K., Kuwasako, K., Nagata, T., Takahashi, M., Kigawa, T., Kobayashi, N., Güntert, P., Shirouzu, M., Yokoyama, S. & Muto, Y. Novel RNA recognition motif domain in cytoplasmic polyadenylation element binding protein 3. Proteins 82, 2879–2886 (2014) PDB 2RUG NMR restraints BMRB 11563
	Kuwasako, K., Takahashi, M., Unzai, S., Tsuda, K., Yoshikawa, S., He, F., Kobayashi, N., Güntert, P., Shirouzu, M., Ito, T., Tanaka, A., Yokoyama, S., Hagiwara, M., Kuroyanagi, H. & Muto, Y. RBFOX and SUP-12 sandwich a guanine base to cooperatively regulate tissue-specific splicing. Nat. Struct. Mol. Biol. 21, 778–786 (2014) PDB 2RU3 NMR restraints BMRB 11517 (SUP-12–RNA6 complex) PDB 2MGZ NMR restraints BMRB 11518 (ASD-1–SUP-12–RNA12 complex)
	Uggerhøj, L. E., Munk, J. K., Hansen, P. R., Güntert, P. & Wimmer, R. Structural features of peptoid-peptide hybrids in lipid-water interfaces. FEBS Lett. 588, 3291–3297 (2014) PDB 2MMJ NMR restraints BMRB 19856 (M-Nleu11) PDB 2MN9 NMR restraints BMRB 19883 (M-Nleu13 trans) PDB 2MN8 NMR restraints BMRB 19882 (M-Nleu13 cis)
	Watson, R. P., Christen, M. T., Bumbak, F., Ewald, C., Reichen, C. Mihajlovic, M., Schmidt, E., Güntert, P., Caflisch, A., Plückthun, A., Zerbe, O. Spontaneous self assembly of fragments of engineered Armadillo repeat proteins into a folded structure. Structure 22, 985–995 (2014) PDB 2RU5 NMR restraints BMRB 11548 (uncomplexed MA) PDB 2RU4 NMR restraints BMRB 11544 (MA-YM2 complex)
	Tufar, P., Rahighi, S., Kraas, F. I., Kirchner, D. K., Löhr, F., Henrich, E., Köpke, J., Dikic, I., Güntert, P., Marahiel, M. A. & Dötsch, V. Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification. Chem. Biol. 21, 552–562 (2014) PDB 2MD9 NMR restraints BMRB 19479
	Kogure, H., Handa, Y., Nagata, M., Kanai, N., Güntert, P., Kubota, K. & Nameki, N. Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ. Nucl. Acids Res. 42, 3152-3163 (2014) PDB 2RTX NMR restraints BMRB 11534
	Luh, L. M., Hänsel, R., Löhr, F., Kirchner, D. K., Krauskopf, K., Pitzius, S., Schäfer, B., Tufar, P., Corbeski, I., Güntert, P. & Dötsch, V. Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition. J. Am. Chem. Soc. 135, 13796−13803 (2013) PDB 2M8I NMR restraints BMRB 19258 (wildtype WW domain) PDB 2M8J NMR restraints BMRB 19259 (WW(S16E) mutant)
	Rogov, V. V., Suzuki, H., Fiskin, E., Wild, P., Kniss, A., Rozenknop, A., Kato, R., Kawasaki, M., McEwan, D. G., Löhr, F., Güntert, P., Dikic, I., Wakatsuki, S. & Dötsch, V. Structural basis for phosphorylation-triggered autophagic clearance of Salmonella. Biochem. J. 454, 459–466 (2013) PDB 2LUE NMR restraints BMRB 18518 (NMR structure of LC3B OPTN-LIR Ptot complex) PDB 3VTU (crystal structure of human LC3B_2-119) PDB 3VTV (crystal structure of Optineurin LIR-fused human LC3B_2-119) PDB 3VTW (crystal structure of T7-tagged Optineurin LIR-fused human LC3B_2-119)
	Lin, Y. J., Ikeya, T., Güntert, P. & Chang, L. S. NMR solution structure of a chymotrypsin inhibitor from the Taiwan cobra. Molecules 18, 8906-8918 (2013) PDB 2M99 NMR restraints BMRB 19287
	He, F., Tsuda, K., Takahashi, M., Kuwasako, K., Terada, T., Shirouzu, M., Watanabe, S., Kigawa, T., Kobayashi, N., Güntert, P., Yokoyama, S. & Muto, Y. Structural insight into the interaction of ADP-ribose with the PARP WWE domains. FEBS Lett. 586, 3858–3864 (2012) PDB 2DK6 NMR restraints BMRB 11500 (WWE domain from PARP11) PDB 1X4R NMR restraints BMRB 11501 (WWE domain from PARP14)
	Christ, N. A., Bochmann, S., Gottstein, D., Duchardt-Ferner, E., Hellmich, U. A., Düsterhus, S., Kötter, P., Güntert, P., Entian, K.-D. & Wöhnert, J. The first structure of a lantibiotic immunity protein, SpaI from Bacillus subtilis, reveals a novel fold. J. Biol. Chem. 287, 35286-35298 (2012) PDB 2LVL NMR restraints BMRB 17534
	Vögeli, B., Kazemi, S., Güntert, P. & Riek, R. Spatial elucidation of motion in proteins by ensemble-based structure calculation using exact NOEs. Nature Struct. Mol. Biol. 19, 1053–1057 (2012) PDB 2LUM NMR restraints BMRB 18531
	Kogure, H., Hikawa, Y., Hagihara, M., Tochio, N., Koshiba, S., Inoue, Y., Güntert, P., Kigawa, T., Yokoyama, S. & Nameki, N. Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65. Proteins 80, 2629–2642 (2012) PDB 2RSM NMR restraints BMRB 11491
	Nagata, T., Tsuda, K., Shirouzu, M., Kigawa, T., Kobayashi, N., Güntert, P., Yokoyama, S. & Muto, Y. Solution structures of the double-stranded RNA-binding domains from RNA-helicase A. Proteins 80, 1699–1706 (2012) PDB 2RS6 NMR restraints BMRB 11456 (dsRBD1) PDB 2RS7 NMR restraints BMRB 11457 (dsRBD2)
	Busche, A., Gottstein, D., Hein, C., Ripin, N., Pader, I., Tufar, P., Eisman, E. B., Gu, L. Walsh, C. T., Sherman, D. H., Löhr, F., Güntert, P. & Dötsch, V. Characterization of the interaction between an ACP domain and a halogenase in the curacin A polyketide synthetase. ACS Chem. Biol. 7, 378–386 (2012) PDB 2LIU NMR restraints BMRB 17906 (holo-ACPI) PDB 2LIW NMR restraints chemical shifts (HMG-ACPI)
	He, F., Inoue, M., Kigawa, T., Takahashi, M., Kuwasako, K., Tsuda, K., Kobayashi, N., Terada, T., Shirouzu, M., Tanaka, A., Sugano, S., Güntert, P., Yokoyama, S. & Muto, Y. Solution structure of the Splicing Factor Motif (SFM) of the human Prp18 protein. Proteins 80, 968–974 (2012) PDB 2DK4 NMR restraints BMRB 11355
	Reckel, S., Gottstein, D., Stehle, J., Löhr, F., Verhoefen, M. K., Takeda, M., Silvers, R., Kainosho, M., Glaubitz, C., Wachtveitl, J., Bernhard, F., Schwalbe, H., Güntert, P. & Dötsch, V. Solution NMR structure of proteorhodopsin. Angew. Chem. Int. Ed. 50, 11942–11946 (2011) PDB 2L6X NMR restraints BMRB 17327
	Rozenknop, A., Rogov, V. V., Löhr, F., Güntert, P., Dikic, I., & Dötsch, V. Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1. J. Mol. Biol. 410, 477–487 (2011) PDB 2L8J NMR restraints BMRB 17412
	Schmöe, K., Rogov, V. V., Rogova, N. Y., Löhr, F., Güntert, P., Bernhard, F. & Dötsch, V. Structural insights into Rcs phosphotransfer: The newly identified RcsD-ABL domain enhances interaction with the response regulator RcsB. Structure 19, 577–587 (2011) PDB 2KX7 NMR restraints
	Tsuda, K., Someya, T., Kuwasako, K., Takahashi, M., Fahu, H., Inoue, M., Harada, T., Watanabe, S., Terada, T., Kobayashi, N., Shirouzu, M., Kigawa, T., Tanaka, A., Sugano, S., Güntert, P., Yokoyama, S. & Muto, Y. Structural basis for the dual RNA-recognition modes of human Tra2-β RRM. Nucl. Acids Res. 39, 1538-1553 (2011) PDB 2RRB NMR restraints
	Yamashita, S., Nagata, T., Kawazoe, M., Takemoto, C., Kigawa, T, Güntert, P., Kobayashi, N., Terada, T., Shirouzu, M., Wakiyama, M., Muto, Y. & Yokoyama, S. Structures of the first and second double-stranded RNA-binding domains of human TAR RNA-binding protein. Protein Sci. 20, 118-130 (2011) PDB 3LLH Structure factors
	Yamashita, S., Nagata, T., Kawazoe, M., Takemoto, C., Kigawa, T, Güntert, P., Kobayashi, N., Terada, T., Shirouzu, M., Wakiyama, M., Muto, Y. & Yokoyama, S. Structures of the first and second double-stranded RNA-binding domains of human TAR RNA-binding protein. Protein Sci. 20, 118-130 (2011) PDB 2CPN NMR restraints
	Handa, Y., Hikawa, Y., Tochio, N., Kogure, H., Inoue, M., Koshiba, S., Güntert, P., Inoue, Y., Kigawa, T., Yokoyama, S. & Nameki, N. Solution structure of the mitochondrial protein ICT1 that is essential for cell vitality. J. Mol. Biol. 404, 260-273 (2010) PDB 1J26
	Hamada, T., Matsunaga, S.,Fujiwara, M., Fujita, K., Hirota, H., Schmucki, R., Güntert, P. & Fusetani, N. Solution structure of polytheonamide B, a highly cytotoxic nonribosomal polypeptide from marine sponge. J. Am. Chem. Soc. 132, 12941–12945 (2010) PDB 2RQO NMR restraints
	He, F., Umehara, T., Saito, K., Harada, T., Watanabe, S., Yobuki, T., Kigawa, T., Takahashi, M., Kuwasako, K., Tsuda, K., Matsuda, T., Aoki, M., Seki, E., Kobayashi, N., Güntert, P., Yokoyama, S. & Muto, Y. Structural insight into the zinc finger CW domain as a histone modification reader. Structure 18, 1127–1139 (2010) PDB 2E61 NMR restraints
	Sobhanifar, S., Schneider, B., Löhr, F., Gottstein, D., Ikeya, T., Filipek, S., Güntert, P., Bernhard, F. & Dötsch, V. Structural investigation of the C-terminal catalytic fragment of presenilin-1. Proc. Natl. Acad. Sci. USA 107, 9644–9649 (2010) PDB 2KR6 NMR restraints
	Coutandin, D., Löhr, F., Niesen, F. H., Ikeya, T., Weber, T. A., Schäfer, B., Bullock, A. N., Yang, A., Güntert, P. , Knapp, S., McKeon, F., Der Ou, H. & Dötsch, V. Conformational stability and activity of p73 require a second helix in the tetramerization domain. Cell Death Diff. 16, 1582–1589 (2009) PDB 2KBY NMR restraints
	He, F., Saito, K., Kobayashi, N., Harada, T., Watanabe, S., Kigawa, T, Güntert, P., Unzai, S., Muto, Y. & Yokoyama, S. Structural and functional characterization of the NHR1 domain of the Drosophila Neuralized E3 ligase in the Notch signaling pathway. J. Mol. Biol. 393, 478-495 (2009) PDB 2YUE NMR restraints PDB 2E63 NMR restraints
	Khayrutdinov, B. I., Bae, W. J., Yun, Y. M., Lee, J. H., Tsuyama, T., Kim, J. J., Hwang, E., Ryu, K. S., Cheong, H. K., Cheong, C., Ko, J. S., Enomoto, T., Karplus, P. A., Güntert, P., Tada, S., Jeon, Y. H., Cho, Y. Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors. Protein Sci. 18, 2252-2264 (2009) PDB 2KLO NMR restraints PDB 3A4C
	Tsuda, K., Kuwasako, K., Takahashi, M., Someya, T., Inoue, M., Terada, T., Kobayashi, N., Shirouzu, M., Kigawa, T., Tanaka, A., Sugano, S., Güntert, P., Muto, Y. & Yokoyama, S. Structural basis for the sequence specific RNA-recognition mechanism of human CUG-BP1 RRM3. Nucl. Acids Res. 37, 5151–5166 (2009) PDB 2RQC NMR restraints PDB 2RQ4 NMR restraints
	He, F., Dang, W., Saito, K., Watanabe, S., Kobayashi, N., Güntert, P., Kigawa, T, Tanaka, A., Muto, Y. & Yokoyama, S. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. Protein Sci. 18, 650–656 (2009) PDB 2RPJ NMR restraints
	Peroza, E. A., Schmucki, R., Güntert, P., Freisinger, E. & Zerbe O. The βE-domain of Wheat Ec-1 metallothionein: A metal-binding domain with a distinctive structure. J. Mol. Biol. 387, 207–218 (2009) PDB 2KAK NMR restraints BMRB 16025
	Sakakibara, D., Sasaki, A., Ikeya, T., Hamatsu, J., Hanashima, T., Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T., Wälchli, M., Smith, B. O., Shirakawa, M., Güntert, P. & Ito, Y. Protein structure determination in living cells by in-cell NMR spectroscopy. Nature 458, 102-105 (2009) PDB 2ROG NMR restraints BMRB 11037 (in-cell) PDB 2ROE NMR restraints BMRB 11035 (in solution)
	He, F., Dang, W., Abe, C., Tsuda, K., Inoue, M., Watanabe, S., Kobayashi, N., Kigawa, T, Matsuda, T., Yabuki, T., Aoki, M., Seki, E., Harada, T., Tomabechi, Y., Terada, T., Shirouzu, M., Tanaka, A., Güntert, P., Muto, Y. & Yokoyama, S. Solution structure of the RNA binding domain in the human muscleblind-like protein 2. Protein Sci. 18, 80-91 (2009) PDB 2E5S　NMR restraints
	Ohnishi, S. Pääkkönen, K., Koshiba, S., Tochio, N., Sato, M., Kobayashi, N., Harada, T., Watanabe, S., Muto, Y., Güntert, P., Tanaka, A., Kigawa, T. & Yokoyama, S. Solution structure of the GUCT domain from human RNA helicase II/Guβ reveals the RRM fold, but implausible RNA interactions. Proteins 74, 133–144 (2009) PDB 2E29
	Takeda, M., Sugimori, N., Torizawa, T., Terauchi, T., Ono, A. M., Yagi, H., Yamaguchi, Y., Kato, K., Ikeya, T., Jee, J., Güntert, P., Aceti, D. J., Markley, J. L. & Kainosho, M. Structure of the putative 32 kDa myrosinase binding protein from Arabidopsis (At3g16450.1) as determined by the SAIL-NMR method. FEBS J. 275, 5873–5884 (2008) PDB 2JZ4 NMR restraints BMRB 15607
	Yoshida, H., Furuya, N., Lin, Y. J., Güntert, P., Komano, T. & Kainosho, M. Structural basis of the role of the NikA ribbon-helix-helix domain in initiating bacterial conjugation. J. Mol. Biol. 384, 690–701 (2008) PDB 2BA3 BMRB 15784
	Lin, Y. J., Umehara, T., Inoue, M., Saito, K., Kigawa, T., Jang, M. K., Ozato, K., Yokoyama, S., Padmanabhan, B., Güntert, P. Solution structure of the extraterminal domain of the bromodomain-containing protein BRD4. Protein Sci. 17, 2174–2179 (2008) PDB 2JNS BMRB 15125
	Koglin, A., Löhr, F., Bernhard, F., Rogov, V. R., Frueh, D. P., Strieter, E. R., Mofid, M. R., Güntert, P., Wagner, G., Walsh, C. T., Marahiel, M. A. & Dötsch, V. Structural basis for the selectivity of the external thioesterase of the surfactin-synthetase. Nature 454, 907–911 (2008) PDB 2RON NMR restraints (SrfTEII) PDB 2K2Q NMR restraints (complex of SrfTEII and H state TycC3–PCP)
	Nagata, T., Suzuki, S., Endo, R., Shirouzu, M., Terada, T., Inoue, M., Kigawa, T, Güntert, P., Hayashizaki, Y., Muto, Y. & Yokoyama, S. The RRM domain of poly(A)-specific ribonuclease (PARN) has a non-canonical binding site for mRNA cap analog recognition. Nucl. Acids Res. 36, 4754–4767 (2008) PDB 1WHV (free form) PDB 2ROK (cap-bound form)
	Takeda, M., Chang, C. K., Ikeya, T., Güntert, P., Chang, Y. H., Hsu, Y. L., Huang, T. H. & Kainosho, M. Solution structure of the C-terminal dimerization domain of SARS coronavirus nucleocapsid protein determined by the SAIL-NMR method. J. Mol. Biol. 380, 608–622 (2008) PDB 2JW8 BMRB 15511
	Kuwasako, K., Takahashi, M., Tochio, N., Abe, C., Tsuda, K., Inoue, M., Terada, T., Shirouzu, M., Kobayashi, N., Kigawa, T., Taguchi, S., Tanaka, A., Hayashizaki, Y., Güntert, P., Muto, Y. & Yokoyama, S. Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode. Biochemistry 47, 6437–6450 (2008) PDB 2RNE
	Kuwasako, K., Dohmae, N., Inoue, M., Shirouzu, M., Taguchi, S., Güntert, P., Séraphin, B., Muto, Y. & Yokoyama, S. Complex assembly mechanism and an RNA-binding mode of the human p14-SF3b155 spliceosomal protein complex identified by NMR solution structure and functional analyses. Proteins 71, 1617–1636 (2008) PDB 2FHO NMR restraints
	Hwang, E., Ryu, K. S., Pääkkönen, K., Güntert, P., Cheong, H. K., Lim, D. S., Lee, J. O., Jeon, Y. H. & Cheong, C. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proc. Natl. Acad. Sci. USA. 104, 9236–9241 (2007) PDB 2JO8 NMR restraints
	Ohnishi, S. Güntert, P., Koshiba, S., Tomizawa, T., Akasaka, R., Tochio, N., Sato, M., Inoue, M., Harada, T., Watanabe, S., Tanaka, T., Shirouzu, M., Kigawa, T. & Yokoyama, S. Solution structure of an atypical WW domain in a novel β-clam-like dimeric form. FEBS Lett. 581, 462–468 (2007) PDB 2DWV
	Kuwasako, K., He, F., Inoue, M., Tanaka, A., Sugano, S., Güntert, P., Muto, Y. & Yokoyama, S. Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP. Structure 14, 1677–1689 (2006) PDB 2DT6 (SURP1) PDB 2DT7 (SURP2-SF3a60)
	ENTH-VHS domain At3g16270(9-135) from Arabidopsis thaliana. López-Méndez, B. & Güntert, P. Automated protein structure determination from NMR spectra. J. Am. Chem. Soc. 128, 13112–13122 (2006) PDB 2DCP NMR restraints Note: Automated structure determination with FLYA. Structure does not supersede the original deposition 1VDY.
	Rhodanese homology domain At3g16270(175-295) from Arabidopsis thaliana. López-Méndez, B. & Güntert, P. Automated protein structure determination from NMR spectra. J. Am. Chem. Soc. 128, 13112–13122 (2006) PDB 2DCQ NMR restraints Note: Automated structure determination with FLYA. Structure does not supersede the original deposition 1VEE.
	Src homology domain 2 from the human feline sarcoma oncogene Fes. López-Méndez, B. & Güntert, P. Automated protein structure determination from NMR spectra. J. Am. Chem. Soc. 128, 13112–13122 (2006) PDB 2DCR NMR restraintsbr>Note: Automated structure determination with FLYA. Structure does not supersede the original deposition 1WQU.
	Jurt, S., Aemissegger, A., Güntert, P., Zerbe, O. & Hilvert, D. A photoswitchable miniprotein based on the sequence of avian pancreatic polypeptide. Angew. Chem. Int. Ed. 45, 6297-6300 (2006) PDB 2H4B NMR restraints (cis-1-PP) PDB 2H3S NMR restraints (cis-1-PP bound to DPC micelles) PDB 2H3T NMR restraints (trans-1-PP bound to DPC micelles)
	Hamada, T., Ito, Y., Abe, T., Hayashi, F., Güntert, P., Inoue, M., Kigawa, T., Terada, T., Shirouzu, M., Yoshida, M., Tanaka, A., Sugano, S., Yokoyama, S. & Hirota, H. Solution structure of the antifreeze-like domain of human sialic acid synthase. Protein Sci. 15, 1010–1016 (2006) PDB 1WVO NMR restraints
	Aachmann, F. L., Svanem, B. I. G., Güntert, P., Petersen, S. B., Valla, S. & Wimmer, R. NMR structure of the R-module - A parallel β-roll subunit from an Azotobacter vinelandii mannuronan C-5 epimerase. J. Biol. Chem. 281, 7350–7356 (2006) PDB 2AGM NMR restraints
	Stereo-array isotope labeled (SAIL) maltodextrin-binding protein MBP. Kainosho, M., Torizawa, T., Iwashita, Y., Terauchi, T., Ono, A. M. & Güntert, P. Optimal isotope labeling for NMR protein structure determinations. Nature 440, 52–57 (2006) PDB 2D21 BMRB 6807
	Stereo-array isotope labeled (SAIL) calmodulin. Kainosho, M., Torizawa, T., Iwashita, Y., Terauchi, T., Ono, A. M. & Güntert, P. Optimal isotope labeling for NMR protein structure determinations. Nature 440, 52–57 (2006) PDB 1X02 BMRB 6541
	Li, H., Inoue, M., Yabuki, T., Aoki, M., Seki, E., Matsuda, T., Nunokawa, E., Motoda, Y., Kobayashi, A., Terada, T., Shirouzu, M., Koshiba, S., Lin, Y. J., Güntert, P., Suzuki, H., Hayashizaki, Y., Kigawa, T. & Yokoyama, S. Solution structure of the mouse enhancer of rudimentary protein reveals a novel fold. J. Biomol. NMR 32, 329–334 (2005) PDB 1WWQ
	Scott, A., Pantoja-Uceda, D., Koshiba, S., Inoue, M., Kigawa, T., Terada, T., Shirouzu, M., Tanaka, A., Sugano, S., Yokoyama, S. & Güntert, P. Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes. J. Biomol. NMR. 31, 357–361 (2005) PDB 1WQU BMRB 6331
	Nameki, N., Tochio, N., Koshiba, S., Inoue, M., Yabuki, T., Aoki, M., Seki, E., Matsuda, T., Fujikura, Y., Saito, M., Ikari, M., Watanabe, M., Terada, T., Shirouzu, M., Yoshida, M., Hirota, H., Tanaka, A., Hayashizaki, Y., Güntert, P., Kigawa, T. & Yokoyama, S. Solution structure of the PWWP domain of the hepatoma-derived growth factor family. Protein Sci. 14, 756–764 (2005) PDB 1N27
	Calzolai, L., Lysek, D. A., Pérez, D. R., Güntert, P. & Wüthrich, K. Prion protein NMR structures of chicken, turtle and frog. Proc. Natl. Acad. Sci. USA 102, 651–655 (2005) PDB 1U3M NMR restraints BMRB 6269 (chicken PrP(121-225)) PDB 1U5L NMR restraints BMRB 6270 (turtle PrP(121-225)) PDB 1XU0 NMR restraints BMRB 6282 (frog PrP(90-222))
	Lysek, D. A., Schorn, C., Nivon, L. G., Esteve-Moya, V., Christen, B., Calzolai, L., von Schroetter, C., Fiorito, F., Herrmann, T., Güntert, P. & Wüthrich, K. Prion protein NMR structures of cat, dog, pig and sheep. Proc. Natl. Acad. Sci. USA 102, 640–645 (2005) PDB 1XYJ NMR restraints BMRB 6377 (cat PrP(121-231)) PDB 1XYK NMR restraints BMRB 6378 (dog PrP(121-231)) PDB 1XYQ NMR restraints BMRB 6380 (pig PrP(121-231)) PDB 1XYU NMR restraints BMRB 6381 (sheep PrP[R168](121-231)) PDB 1Y2S BMRB 6403 (sheep PrP[H168](121-231))
	Pääkkönen, K., Tossavainen, H., Permi, P., Rakkolainen, H., Rauvala, H., Raulo, E., Kilpeläinen, I. & Güntert, P. Solution structures of the first and fourth TSR domains of F-spondin. Proteins 64, 665–672 (2006) PDB 1SZL　NMR restraints BMRB 6175 (TSR1) PDB 1VEX (TSR4)
	ENTH-VHS domain At3g16270 from Arabidopsis thaliana. PDB 1VDY BMRB 5928
	Iwai, H., Forrer, P., Plückthun, A. & Güntert, P. NMR solution structure of the monomeric form of the bacteriophage λ capsid stabilizing protein gpD. J. Biomol. NMR. 31, 351–356 (2005) PDB 1VD0 BMRB 4936
	Pantoja-Uceda, D., López-Méndez, B., Koshiba, S., Inoue, M., Kigawa, T., Terada, T., Shirouzu, M., Tanaka, A., Seki, M., Shinozaki, K., Yokoyama, S. & Güntert, P. Solution structure of the rhodanese homology domain At4g01050(175–295) from Arabidopsis thaliana. Protein Sci. 14, 224–230 (2005) PDB 1VEE BMRB 5929
	Nameki, N., Yoneyama, M., Koshiba, S., Tochio, N., Inoue, M., Seki, E., Matsuda, T., Tomo, Y., Harada, T., Saito, K., Kobayashi, N., Yabuki, T., Aoki, M., Nunokawa, E., Matsuda, N., Sakagami, N., Terada, T., Shirouzu, M., Yoshida, M., Hirota, H., Osanai, T., Tanaka, A., Arakawa, T., Carninci, P., Kawai, J., Hayashizaki, Y., Kinoshita, K., Güntert, P., Kigawa, T. & Yokoyama, S. Solution structure of the RWD domain of the mouse GCN2 protein. Protein Sci. 13, 2089–2100 (2004) PDB 1UKX BMRB 6297
	Fernández, C., Hilty, C., Wider, G., Güntert, P. & Wüthrich, K. NMR structure of the integral membrane protein OmpX. J. Mol. Biol. 336, 1211–1221 (2004) PDB 1Q9G BMRB 4936
	FHA domain of mouse afadin 6. PDB 1WLN
	Vanwetswinkel, S., Kriek, J., Andersen, G. R., Güntert, P., Dijk, P., Canters, G. W. & Siegal, G. Solution structure of the 162 residue C-terminal domain of human elongation factor 1Bγ. J. Biol. Chem. 278, 43443–43451 (2003) PDB 1PBU NMR restraints BMRB 5628
	Hilge, M., Siegal, G., Vuister, G. W., Güntert, P., Gloor, S. M. & Abrahams, J. P. ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase. Nat. Struct. Biol. 10, 468–474 (2003) PDB 1MO7 BMRB 5577 (free form) PDB 1MO8 BMRB 5576 (ATP-bound form)
	Lührs, T., Riek, R., Güntert, P. & Wüthrich, K. NMR structure of the human doppel protein. J. Mol. Biol. 326, 1549–1557 (2003) PDB 1LG4 NMR restraints BMRB 5145
	Zahn, R., Güntert, P. & Wüthrich, K. NMR structure of a variant human prion protein with two disulfide bonds. J. Mol. Biol. 326, 225–234 (2003) PDB 1H0L NMR restraints BMRB 5378
	Enggist, E., Thöny-Meyer, L., Güntert, P. & Pervushin, K. NMR structure of the heme chaperone CcmE reveals a new functional motif. Structure 10, 1551–1557 (2002) PDB 1SR3 NMR restraints
	Lee, D., Damberger, F. D., Peng, G., Horst, R., Güntert, P., Nikonova, L., Leal, W. S. & Wüthrich, K. NMR structure of the unliganded Bombyx mori pheromone-binding protein at physiological pH. FEBS Lett. 531, 314–318 (2002) PDB 1LS8
	Ellgaard, L., Bettendorff, P., Braun, D., Herrmann, T., Fiorito, F., Jelesarov, I., Güntert, P., Helenius, A. & Wüthrich, K. NMR Structures of 36 and 73-residue fragments of the calreticulin P-domain. J. Mol. Biol. 322, 773–784 (2002) PDB 1K9C NMR restraints BMRB 5204 (residues 189-261) PDB 1K91 NMR restraints BMRB 5205 (residues 221-256)
	Miura, T., Klaus, W., Ross, A., Güntert, P., Senn, H. The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. J. Biomol. NMR 22, 89–92 (2002) PDB 1JAS NMR restraints BMRB 5038
	Horst, R., Damberger, F., Luginbühl, P., Güntert, P., Peng, G., Nikonova, L., Leal, W. S. & Wüthrich, K. NMR structure reveals intramolecular regulation mechanism for pheromone binding and release. Proc. Natl. Acad. Sci. USA 98, 14374–14379 (2001) PDB 1GM0 NMR restraints BMRB 4849
	Ellgaard, L., Riek, R., Herrmann, T., Güntert, P., Braun, D., Helenius, A. & Wüthrich, K. NMR structure of the calreticulin P-domain. Proc. Natl. Acad. Sci. USA 98, 3133–3138 (2001) PDB 1HHN BMRB 4878
	Calzolai, L., Lysek, D. A., Güntert, P., von Schroetter, C., Riek, R., Zahn, R. & Wüthrich, K. NMR structures of three single-residue variants of the human prion protein. Proc. Natl. Acad. Sci. USA 97, 8340–8345 (2000) PDB 1E1G NMR restraints BMRB 4736 (variant M166V) PDB 1E1P NMR restraints (variant S170N) PDB 1E1U NMR restraints BMRB 4620 (variant R220K)
	Riek, R., Prêcheur, B., Wang, Y., Wider, G., Güntert, P., Liu, A., Kägi, J. H. R. & Wüthrich, K. NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA. J. Mol. Biol. 291, 417–428 (1999) PDB 1QJK NMR restraints (α domain) PDB 1QJL NMR restraints (β domain) BMRB 4363
	Pellecchia, M., Güntert, P., Glockshuber, R. & Wüthrich, K. The NMR solution structure of the periplasmic chaperone FimC. Nature Struct. Biol. 5, 885–890 (1998) PDB 1BF8 NMR restraints BMRB 4070
	Ottiger, M., Zerbe, O., Güntert, P. & Wüthrich, K. The NMR solution conformation of unligated human Cyclophilin A. J. Mol. Biol. 272, 64–81 (1997) PDB 1OCA NMR restraints
	Antuch, W., Güntert, P. & Wüthrich, K. Ancestral βγ-crystallin precursor structure in a yeast killer toxin. Nature Struct. Biol. 3, 662–665 (1996) PDB 1WKT NMR restraints BMRB 5255
	Antuch, W., Güntert, P., Billeter, M., Hawthorne, T., Grossenbacher, H. & Wüthrich, K. NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata. FEBS Lett. 352, 251–257 (1994) PDB 1TAP NMR restraints
	Berndt, K. D., Güntert, P. & Wüthrich, K. The NMR solution structure of dendrotoxin K from the venom of Dendroaspis polylepis polylepis. J. Mol. Biol. 234, 735–750 (1993) PDB 1DTK NMR restraints
	Szyperski, T., Güntert, P., Stone, S. R. & Wüthrich, K. NMR solution structure of hirudin(1–51) and comparison with corresponding three-dimensional structures determined using the complete 65-residue hirudin polypeptide chain. J. Mol. Biol. 228, 1193–1205 (1992) PDB 1HIC NMR restraintsBMRB 1128
	Berndt, K. D., Güntert, P., Orbons, L. P. M. & Wüthrich, K. Determination of a high-quality NMR solution structure of the bovine pancreatic trypsin inhibitor (BPTI) and comparison with three crystal structures. J. Mol. Biol. 227, 757–775 (1992) PDB 1PIT NMR restraints
	Güntert, P., Qian, Y. Q., Otting, G., Müller, M., Gehring, W. J. & Wüthrich K. Structure determination of the Antp(C39S) homeodomain from nuclear magnetic resonance data in solution using a novel strategy for the structure calculation with the programs DIANA, CALIBA, HABAS and GLOMSA. J. Mol. Biol. 217, 531–540 (1991) PDB 2HOA