data_O33
# 
_chem_comp.id                                    O33 
_chem_comp.name                                  (4R)-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-3-[(2S,3S)-2-HYDROXY-3-({N-[(ISOQUINOLIN-5-YLOXY)ACETYL]-S-METHYL-L-CYSTEINYL}AMINO)-4-PHENYLBUTANOYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE 
_chem_comp.type                                  NON-POLYMER 
_chem_comp.pdbx_type                             HETAIN 
_chem_comp.formula                               "C40 H45 N5 O7 S2" 
_chem_comp.mon_nstd_parent_comp_id               ? 
_chem_comp.pdbx_synonyms                         ? 
_chem_comp.pdbx_formal_charge                    0 
_chem_comp.pdbx_initial_date                     2007-04-18 
_chem_comp.pdbx_modified_date                    2008-10-14 
_chem_comp.pdbx_ambiguous_flag                   ? 
_chem_comp.pdbx_release_status                   REL 
_chem_comp.pdbx_replaced_by                      ? 
_chem_comp.pdbx_replaces                         ? 
_chem_comp.formula_weight                        771.945 
_chem_comp.one_letter_code                       ? 
_chem_comp.three_letter_code                     O33 
_chem_comp.pdbx_model_coordinates_details        ? 
_chem_comp.pdbx_model_coordinates_missing_flag   N 
_chem_comp.pdbx_ideal_coordinates_details        "OpenEye OEToolkits" 
_chem_comp.pdbx_ideal_coordinates_missing_flag   N 
_chem_comp.pdbx_model_coordinates_db_code        ? 
_chem_comp.pdbx_subcomponent_list                ? 
_chem_comp.pdbx_processing_site                  RCSB 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.alt_atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.charge 
_chem_comp_atom.pdbx_align 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_leaving_atom_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.model_Cartn_x 
_chem_comp_atom.model_Cartn_y 
_chem_comp_atom.model_Cartn_z 
_chem_comp_atom.pdbx_model_Cartn_x_ideal 
_chem_comp_atom.pdbx_model_Cartn_y_ideal 
_chem_comp_atom.pdbx_model_Cartn_z_ideal 
_chem_comp_atom.pdbx_component_atom_id 
_chem_comp_atom.pdbx_component_comp_id 
_chem_comp_atom.pdbx_ordinal 
O33 C1   C1   C 0 1 N N N 18.034 -23.965 -17.173 -12.491 1.601  -8.057  C1   O33 1  
O33 C2   C2   C 0 1 N N N 15.953 -23.889 -18.386 -10.487 2.523  -6.905  C2   O33 2  
O33 C3   C3   C 0 1 N N N 14.885 -22.885 -18.068 -9.229  3.177  -7.474  C3   O33 3  
O33 C4   C4   C 0 1 N N N 14.350 -20.627 -17.412 -7.410  4.755  -6.862  C4   O33 4  
O33 C5   C5   C 0 1 N N N 14.220 -19.760 -18.659 -6.218  3.858  -6.512  C5   O33 5  
O33 C6   C6   C 0 1 N N N 12.924 -19.008 -18.591 -4.927  4.515  -6.932  C6   O33 6  
O33 C7   C7   C 0 1 N N N 14.885 -19.875 -16.184 -7.397  6.107  -6.122  C7   O33 7  
O33 C8   C8   C 0 1 Y N N 15.155 -20.894 -15.096 -8.298  7.137  -6.765  C8   O33 8  
O33 C9   C9   C 0 1 Y N N 16.480 -21.144 -14.733 -9.619  7.228  -6.359  C9   O33 9  
O33 C11  C11  C 0 1 Y N N 15.676 -22.740 -13.132 -9.949  9.023  -7.942  C11  O33 10 
O33 C12  C12  C 0 1 Y N N 14.348 -22.488 -13.460 -8.616  8.919  -8.339  C12  O33 11 
O33 C14  C14  C 0 1 N N N 11.866 -20.770 -19.984 -5.171  3.314  -9.138  C14  O33 12 
O33 C16  C16  C 0 1 N N N 10.647 -18.739 -19.229 -3.252  4.798  -8.752  C16  O33 13 
O33 C18  C18  C 0 1 N N N 8.269  -19.093 -20.245 -1.759  4.502  -10.832 C18  O33 14 
O33 C19  C19  C 0 1 N N N 10.215 -18.635 -21.664 -1.844  2.727  -9.065  C19  O33 15 
O33 C20  C20  C 0 1 N N N 15.302 -25.159 -18.959 -10.226 1.708  -5.635  C20  O33 16 
O33 C21  C21  C 0 1 N N N 18.815 -24.337 -15.926 -12.869 0.726  -9.233  C21  O33 17 
O33 C22  C22  C 0 1 N N N 16.410 -25.193 -21.431 -9.135  -0.362 -4.207  C22  O33 18 
O33 C27  C27  C 0 1 Y N N 18.180 -26.073 -11.469 -16.105 -2.564 -9.734  C27  O33 19 
O33 C28  C28  C 0 1 Y N N 17.692 -25.811 -12.759 -15.624 -1.380 -9.138  C28  O33 20 
O33 C29  C29  C 0 1 Y N N 17.381 -26.798 -10.584 -16.956 -3.369 -8.974  C29  O33 21 
O33 C30  C30  C 0 1 Y N N 15.686 -26.994 -12.195 -16.868 -1.947 -7.172  C30  O33 22 
O33 C31  C31  C 0 1 Y N N 16.426 -26.259 -13.129 -16.018 -1.072 -7.831  C31  O33 23 
O33 C32  C32  C 0 1 N N N 8.346  -17.397 -16.545 -3.392  8.572  -9.073  C32  O33 24 
O33 O4   O4   O 0 1 N N N 9.857  -19.729 -17.139 -4.484  6.153  -10.247 O4   O33 25 
O33 C17  C17  C 0 1 N N N 9.880  -18.733 -17.915 -3.688  6.124  -9.315  C17  O33 26 
O33 N4   N4   N 0 1 N N N 9.224  -17.584 -17.702 -3.115  7.216  -8.692  N4   O33 27 
O33 C33  C33  C 0 1 Y N N 8.898  -16.788 -15.318 -3.218  9.580  -7.972  C33  O33 28 
O33 C37  C37  C 0 1 Y N N 10.133 -17.072 -14.723 -3.589  9.486  -6.639  C37  O33 29 
O33 C38  C38  C 0 1 Y N N 10.468 -16.410 -13.535 -3.370  10.587 -5.808  C38  O33 30 
O33 C39  C39  C 0 1 Y N N 9.575  -15.467 -13.006 -2.803  11.766 -6.315  C39  O33 31 
O33 C40  C40  C 0 1 Y N N 8.332  -15.214 -13.601 -2.448  11.862 -7.661  C40  O33 32 
O33 C34  C34  C 0 1 Y N N 8.020  -15.901 -14.771 -2.656  10.761 -8.476  C34  O33 33 
O33 C35  C35  C 0 1 N N N 6.765  -15.778 -15.607 -2.388  10.649 -9.948  C35  O33 34 
O33 C36  C36  C 0 1 N N N 7.216  -16.422 -16.917 -2.420  9.122  -10.141 C36  O33 35 
O33 O7   O7   O 0 1 N N N 7.735  -15.408 -17.791 -1.104  8.605  -9.928  O7   O33 36 
O33 C15  C15  C 0 1 N N N 9.780  -19.317 -20.361 -2.642  3.828  -9.780  C15  O33 37 
O33 S1   S1   S 0 1 N N N 10.181 -21.064 -20.353 -4.099  3.058  -10.571 S1   O33 38 
O33 N3   N3   N 0 1 N N N 11.885 -19.513 -19.234 -4.479  4.206  -8.213  N3   O33 39 
O33 O2   O2   O 0 1 N N N 12.856 -17.994 -17.940 -4.337  5.270  -6.156  O2   O33 40 
O33 O1   O1   O 0 1 N N N 15.317 -18.832 -18.719 -6.132  3.627  -5.121  O1   O33 41 
O33 C10  C10  C 0 1 Y N N 16.737 -22.092 -13.759 -10.451 8.178  -6.952  C10  O33 42 
O33 C13  C13  C 0 1 Y N N 14.084 -21.541 -14.457 -7.785  7.968  -7.746  C13  O33 43 
O33 N2   N2   N 0 1 N N N 15.324 -21.655 -17.764 -8.632  4.033  -6.564  N2   O33 44 
O33 O3   O3   O 0 1 N N N 13.697 -23.218 -18.081 -8.803  2.939  -8.602  O3   O33 45 
O33 S2   S2   S 0 1 N N N 14.872 -24.817 -20.648 -9.066  0.324  -5.877  S2   O33 46 
O33 N1   N1   N 0 1 N N N 16.726 -24.257 -17.211 -11.115 1.741  -7.939  N1   O33 47 
O33 O5   O5   O 0 1 N N N 18.635 -23.397 -18.063 -13.325 2.112  -7.314  O5   O33 48 
O33 O6   O6   O 0 1 N N N 17.972 -24.875 -14.917 -14.273 0.611  -9.338  O6   O33 49 
O33 C23  C23  C 0 1 Y N N 18.479 -25.103 -13.662 -14.768 -0.554 -9.875  C23  O33 50 
O33 C24  C24  C 0 1 Y N N 19.742 -24.632 -13.288 -14.391 -0.881 -11.174 C24  O33 51 
O33 C25  C25  C 0 1 Y N N 20.229 -24.894 -11.993 -14.868 -2.051 -11.759 C25  O33 52 
O33 C26  C26  C 0 1 Y N N 19.451 -25.617 -11.082 -15.722 -2.892 -11.045 C26  O33 53 
O33 N5   N5   N 0 1 Y N N 16.170 -27.234 -10.973 -17.348 -3.088 -7.711  N5   O33 54 
O33 H2   H2   H 0 1 N N N 16.634 -23.427 -19.116 -11.198 3.324  -6.668  H2   O33 55 
O33 H4   H4   H 0 1 N N N 13.355 -21.005 -17.134 -7.424  4.922  -7.947  H4   O33 56 
O33 H5   H5   H 0 1 N N N 14.237 -20.393 -19.559 -6.281  2.900  -7.034  H5   O33 57 
O33 H71  1H7  H 0 1 N N N 15.814 -19.345 -16.442 -7.726  5.979  -5.083  H71  O33 58 
O33 H72  2H7  H 0 1 N N N 14.150 -19.133 -15.839 -6.375  6.505  -6.068  H72  O33 59 
O33 H9   H9   H 0 1 N N N 17.290 -20.607 -15.204 -10.019 6.573  -5.589  H9   O33 60 
O33 H11  H11  H 0 1 N N N 15.892 -23.466 -12.362 -10.597 9.763  -8.404  H11  O33 61 
O33 H12  H12  H 0 1 N N N 13.544 -23.008 -12.960 -8.226  9.577  -9.109  H12  O33 62 
O33 H141 1H14 H 0 0 N N N 12.285 -21.591 -19.383 -5.383  2.364  -8.638  H141 O33 63 
O33 H142 2H14 H 0 0 N N N 12.479 -20.710 -20.896 -6.115  3.778  -9.440  H142 O33 64 
O33 H16  H16  H 0 1 N N N 10.905 -17.680 -19.375 -2.550  5.022  -7.941  H16  O33 65 
O33 H181 1H18 H 0 0 N N N 7.986  -19.039 -19.183 -2.367  4.876  -11.661 H181 O33 66 
O33 H182 2H18 H 0 0 N N N 7.999  -18.151 -20.744 -1.216  5.345  -10.395 H182 O33 67 
O33 H183 3H18 H 0 0 N N N 7.737  -19.928 -20.724 -1.029  3.792  -11.232 H183 O33 68 
O33 H191 1H19 H 0 0 N N N 10.319 -17.553 -21.495 -1.577  1.930  -9.766  H191 O33 69 
O33 H192 2H19 H 0 0 N N N 11.180 -19.050 -21.990 -0.922  3.134  -8.640  H192 O33 70 
O33 H193 3H19 H 0 0 N N N 9.457  -18.813 -22.441 -2.433  2.289  -8.254  H193 O33 71 
O33 H201 1H20 H 0 0 N N N 16.007 -26.002 -18.910 -9.814  2.347  -4.847  H201 O33 72 
O33 H202 2H20 H 0 0 N N N 14.408 -25.433 -18.379 -11.166 1.287  -5.263  H202 O33 73 
O33 H211 1H21 H 0 0 N N N 19.570 -25.091 -16.194 -12.488 1.175  -10.154 H211 O33 74 
O33 H212 2H21 H 0 0 N N N 19.285 -23.425 -15.530 -12.434 -0.271 -9.115  H212 O33 75 
O33 H221 1H22 H 0 0 N N N 16.259 -25.271 -22.518 -8.218  -0.918 -3.995  H221 O33 76 
O33 H222 2H22 H 0 0 N N N 17.135 -24.393 -21.218 -9.990  -1.037 -4.119  H222 O33 77 
O33 H223 3H22 H 0 0 N N N 16.794 -26.149 -21.045 -9.240  0.445  -3.479  H223 O33 78 
O33 H29  H29  H 0 1 N N N 17.736 -27.009 -9.586  -17.362 -4.294 -9.373  H29  O33 79 
O33 H30  H30  H 0 1 N N N 14.711 -27.372 -12.466 -17.196 -1.743 -6.158  H30  O33 80 
O33 H31  H31  H 0 1 N N N 16.026 -26.045 -14.109 -15.679 -0.174 -7.323  H31  O33 81 
O33 H32  H32  H 0 1 N N N 8.075  -18.439 -16.317 -4.425  8.622  -9.434  H32  O33 82 
O33 HN4  HN4  H 0 1 N N N 9.337  -16.833 -18.352 -2.467  7.051  -7.927  HN4  O33 83 
O33 H37  H37  H 0 1 N N N 10.811 -17.784 -15.169 -4.044  8.584  -6.244  H37  O33 84 
O33 H38  H38  H 0 1 N N N 11.401 -16.623 -13.034 -3.649  10.534 -4.759  H38  O33 85 
O33 H39  H39  H 0 1 N N N 9.853  -14.921 -12.116 -2.646  12.614 -5.653  H39  O33 86 
O33 H40  H40  H 0 1 N N N 7.639  -14.509 -13.166 -2.021  12.779 -8.054  H40  O33 87 
O33 H351 1H35 H 0 0 N N N 5.910  -16.303 -15.156 -3.197  11.136 -10.502 H351 O33 88 
O33 H352 2H35 H 0 0 N N N 6.399  -14.746 -15.717 -1.419  11.082 -10.214 H352 O33 89 
O33 H36  H36  H 0 1 N N N 6.386  -16.934 -17.426 -2.714  8.838  -11.156 H36  O33 90 
O33 HO7  HO7  H 0 1 N N N 7.850  -14.599 -17.306 -0.508  9.367  -9.940  HO7  O33 91 
O33 HO1  HO1  H 0 1 N N N 15.510 -18.627 -19.626 -7.037  3.464  -4.799  HO1  O33 92 
O33 H10  H10  H 0 1 N N N 17.755 -22.328 -13.486 -11.489 8.260  -6.644  H10  O33 93 
O33 H13  H13  H 0 1 N N N 13.066 -21.310 -14.733 -6.747  7.894  -8.061  H13  O33 94 
O33 HN2  HN2  H 0 1 N N N 16.302 -21.446 -17.778 -9.072  4.207  -5.669  HN2  O33 95 
O33 HN1  HN1  H 0 1 N N N 16.288 -24.722 -16.441 -10.521 1.268  -8.616  HN1  O33 96 
O33 H24  H24  H 0 1 N N N 20.341 -24.070 -13.989 -13.726 -0.232 -11.738 H24  O33 97 
O33 H25  H25  H 0 1 N N N 21.206 -24.536 -11.702 -14.575 -2.310 -12.773 H25  O33 98 
O33 H26  H26  H 0 1 N N N 19.825 -25.823 -10.090 -16.084 -3.802 -11.517 H26  O33 99 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
O33 C1  O5   DOUB N N 1   
O33 C1  N1   SING N N 2   
O33 C1  C21  SING N N 3   
O33 C2  C20  SING N N 4   
O33 C2  C3   SING N N 5   
O33 C2  N1   SING N N 6   
O33 C2  H2   SING N N 7   
O33 C3  O3   DOUB N N 8   
O33 C3  N2   SING N N 9   
O33 C4  C5   SING N N 10  
O33 C4  N2   SING N N 11  
O33 C4  C7   SING N N 12  
O33 C4  H4   SING N N 13  
O33 C5  O1   SING N N 14  
O33 C5  C6   SING N N 15  
O33 C5  H5   SING N N 16  
O33 C6  N3   SING N N 17  
O33 C6  O2   DOUB N N 18  
O33 C7  C8   SING N N 19  
O33 C7  H71  SING N N 20  
O33 C7  H72  SING N N 21  
O33 C8  C9   DOUB Y N 22  
O33 C8  C13  SING Y N 23  
O33 C9  C10  SING Y N 24  
O33 C9  H9   SING N N 25  
O33 C11 C10  DOUB Y N 26  
O33 C11 C12  SING Y N 27  
O33 C11 H11  SING N N 28  
O33 C12 C13  DOUB Y N 29  
O33 C12 H12  SING N N 30  
O33 C14 S1   SING N N 31  
O33 C14 N3   SING N N 32  
O33 C14 H141 SING N N 33  
O33 C14 H142 SING N N 34  
O33 C16 C15  SING N N 35  
O33 C16 N3   SING N N 36  
O33 C16 C17  SING N N 37  
O33 C16 H16  SING N N 38  
O33 C18 C15  SING N N 39  
O33 C18 H181 SING N N 40  
O33 C18 H182 SING N N 41  
O33 C18 H183 SING N N 42  
O33 C19 C15  SING N N 43  
O33 C19 H191 SING N N 44  
O33 C19 H192 SING N N 45  
O33 C19 H193 SING N N 46  
O33 C20 S2   SING N N 47  
O33 C20 H201 SING N N 48  
O33 C20 H202 SING N N 49  
O33 C21 O6   SING N N 50  
O33 C21 H211 SING N N 51  
O33 C21 H212 SING N N 52  
O33 C22 S2   SING N N 53  
O33 C22 H221 SING N N 54  
O33 C22 H222 SING N N 55  
O33 C22 H223 SING N N 56  
O33 C27 C28  SING Y N 57  
O33 C27 C26  SING Y N 58  
O33 C27 C29  DOUB Y N 59  
O33 C28 C23  SING Y N 60  
O33 C28 C31  DOUB Y N 61  
O33 C29 N5   SING Y N 62  
O33 C29 H29  SING N N 63  
O33 C30 C31  SING Y N 64  
O33 C30 N5   DOUB Y N 65  
O33 C30 H30  SING N N 66  
O33 C31 H31  SING N N 67  
O33 C32 N4   SING N N 68  
O33 C32 C36  SING N N 69  
O33 C32 C33  SING N N 70  
O33 C32 H32  SING N N 71  
O33 O4  C17  DOUB N N 72  
O33 C17 N4   SING N N 73  
O33 N4  HN4  SING N N 74  
O33 C33 C34  DOUB Y N 75  
O33 C33 C37  SING Y N 76  
O33 C37 C38  DOUB Y N 77  
O33 C37 H37  SING N N 78  
O33 C38 C39  SING Y N 79  
O33 C38 H38  SING N N 80  
O33 C39 C40  DOUB Y N 81  
O33 C39 H39  SING N N 82  
O33 C40 C34  SING Y N 83  
O33 C40 H40  SING N N 84  
O33 C34 C35  SING N N 85  
O33 C35 C36  SING N N 86  
O33 C35 H351 SING N N 87  
O33 C35 H352 SING N N 88  
O33 C36 O7   SING N N 89  
O33 C36 H36  SING N N 90  
O33 O7  HO7  SING N N 91  
O33 C15 S1   SING N N 92  
O33 O1  HO1  SING N N 93  
O33 C10 H10  SING N N 94  
O33 C13 H13  SING N N 95  
O33 N2  HN2  SING N N 96  
O33 N1  HN1  SING N N 97  
O33 O6  C23  SING N N 98  
O33 C23 C24  DOUB Y N 99  
O33 C24 C25  SING Y N 100 
O33 C24 H24  SING N N 101 
O33 C25 C26  DOUB Y N 102 
O33 C25 H25  SING N N 103 
O33 C26 H26  SING N N 104 
# 
loop_
_pdbx_chem_comp_descriptor.comp_id 
_pdbx_chem_comp_descriptor.type 
_pdbx_chem_comp_descriptor.program 
_pdbx_chem_comp_descriptor.program_version 
_pdbx_chem_comp_descriptor.descriptor 
O33 SMILES           ACDLabs              10.04 O=C(NC2c1ccccc1CC2O)C6N(C(=O)C(O)C(NC(=O)C(NC(=O)COc4c3ccncc3ccc4)CSC)Cc5ccccc5)CSC6(C)C 
O33 InChI            InChI                1.02b 
;InChI=1/C40H45N5O7S2/c1-40(2)36(38(50)44-34-28-14-8-7-12-25(28)19-31(34)46)45(23-54-40)39(51)35(48)29(18-24-10-5-4-6-11-24)43-37(49)30(22-53-3)42-33(47)21-52-32-15-9-13-26-20-41-17-16-27(26)32/h4-17,20,29-31,34-36,46,48H,18-19,21-23H2,1-3H3,(H,42,47)(H,43,49)(H,44,50)/t29-,30-,31+,34-,35-,36+/m0/s1/f/h42-44H
;
O33 InChIKey         InChI                1.02b NLPSIHQYIUXYOW-PCKKSTGUDH 
O33 SMILES_CANONICAL CACTVS               3.341 CSC[C@H](NC(=O)COc1cccc2cnccc12)C(=O)N[C@@H](Cc3ccccc3)[C@H](O)C(=O)N4CSC(C)(C)[C@H]4C(=O)N[C@@H]5[C@H](O)Cc6ccccc56 
O33 SMILES           CACTVS               3.341 CSC[CH](NC(=O)COc1cccc2cnccc12)C(=O)N[CH](Cc3ccccc3)[CH](O)C(=O)N4CSC(C)(C)[CH]4C(=O)N[CH]5[CH](O)Cc6ccccc56 
O33 SMILES_CANONICAL "OpenEye OEToolkits" 1.5.0 CC1([C@H](N(CS1)C(=O)[C@H]([C@H](Cc2ccccc2)NC(=O)[C@H](CSC)NC(=O)COc3cccc4c3ccnc4)O)C(=O)N[C@H]5c6ccccc6C[C@H]5O)C 
O33 SMILES           "OpenEye OEToolkits" 1.5.0 CC1(C(N(CS1)C(=O)C(C(Cc2ccccc2)NC(=O)C(CSC)NC(=O)COc3cccc4c3ccnc4)O)C(=O)NC5c6ccccc6CC5O)C 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
O33 "SYSTEMATIC NAME" ACDLabs              10.04 (4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide 
O33 "SYSTEMATIC NAME" "OpenEye OEToolkits" 1.5.0 
(4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-[[(2R)-2-(2-isoquinolin-5-yloxyethanoylamino)-3-methylsulfanyl-propanoyl]amino]-4-phenyl-butanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide 
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